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参考文献

1) T. Miyata, Pharmacological basis of traditional medicines and health supplements as curatives, J. Pharmacol. Sci., 2007, 103, 127-131.

2) J. Fuchikami, K. Takahama, H. Kai, T. Miyata, Comparative study of the antitussive activity of Mai-Meu-Dong-Tang and codeine in normal and bronchitic guinea-pigs, Life Sci. Adv., 1990, 9, 37-43.

3) K. Takahama, I. Wakuda, H. Fukushima, Y. Isohama, H. Kai, T. Miyata, Differential effect of codeine on cough caused by mechanical stimulation of two different sites in the airway of guinea-pigs, Eur. J. Pharmacol., 1997, 329, 93-97.

4) K. Takahama, J. Fuchikami, Y. Isoham, H. Kai, T. Miyata, Inhalation of phosphoramidon, a neutral endopeptidase inhibitor, induces coughs in awake guinea-pigs, Arch. Int. Pharmacodyn. Ther., 1996, 330, 241-250.

5) K. Takahama, T. Araki, J. Fuchikami, Y. Kohjimoto, T. Miyata, Studies on the magnitude and the mechanism of cough potentiation by ACE inhibitors in guinea pigs. Involvement of bradykinin in potentiation, J. Pharm. Pharmacol., 1996, 48, 1027- 1033.

6) T. Miyata, Pharmacological characteristics of traditional medicine as curative‘ Polypharmacy’, J. Trad. Med., 2004, 21, 155-165.

7) H. Kai, K. Yoshitake, A. Hisatsune, T. Kido, Y. Isohama, K. Takahama, et al., Dexamethasone suppresses the mucus production and MUC-2 and MUC-5 gene expression by NCI-H292 cells, Am. J. Physiol., 1996, 271, L484-L488.

8) T. Miyata, Y. Isohama, K. Takahama, H. Kai, Current opinion of muco-active drug research: strategies and problems, Eur. Respir. J., 1998, 11, 480-491.

9) S. Tai, H. Kai, Y. Isohama, H. Moriuchi, N. Hagino, T. Miyata, The effect of Maimendongtang on airway clearance and secretion, Phytother. Res., 1999, 13, 124-127.

10) T. Miyata, Y. Isohama, S. Tai, H. Kai, K. Takahama, Pathopharmacological evaluation of Bakumondo-to (Maimengdongtang) as a curative for chronic inflammatory airway diseases. In: H. Watanabe, T. Shibuya , editors. Pharmacological research on traditional herbal medicine, Amsterdam: Harwood Academic Publishers, 1999, 121-147.

11) H. Kai, Y. Isohama, K. Takaki, Y. Oda, K. Murahara, K. Takahama, et al., Both b1- and b2-adrenoceptors are involved in mediating phosphatidylcholine secretion in rat type II pneumocyte cultures, Eur. J. Pharmacol., 1992, 212, 101-103.

12) Y. Isohama, T. Matsuo, H. Kai, K. Takahama, T. Miyata , Changes in b1- and b2-adrenoceptor mRNA levels in alveolar type II cells during cultivation, Biochem. Mol. Biol. Int., 1995, 36, 561-568.

13) Y. Isohama, K. Kurita, H. Kai, K. Takahama, T. Miyata, Bakumondo-to (Mai-Men-Dong-Tang) increases b1-adrenergic receptor mRNA expression in rat alveolar type II cells, J. Trad. Med., 2001, 18, 8-14.

14) Y. Isohama, K. Kurita, H. Kai, K. Takahama, T. Miyata, Bakumondo-to (Mai-Men-Dong-Tang) increases intracellular cAMP in alveolar type II cells: Bakumondo-to stimulated production and inhibits degradation of cAMP, J. Trad. Med., 2001, 18,15-19.

15) Y. Isohama, H. Moriuchi, H. Kai, T. Miyata, Glucocorticoidlike and glucocorticoid-unlike regulation of gene expression by Bakumondo-to (Mai-Men-Dong-Tang) in airway epithelial cells, Jpn. J. Orient. Med., 2002, 53, 1-9.

16) Y. Isohama, Y. Kumanda, K. Tanaka, K. Kai, K. Takahama, T. Miyata, Dexamethasone increases b2-adrenoceptor-regulated phosphatidylcholine secretion in rat alveolar type II cells., Jpn. J. Pharmacol., 1997, 73, 163-169.

17) H. Takei, Y. Baba, T. Hisatsune, H. Katsuki, T. Miyata, K. Yokomizo and Y. Isohama, Glycyrrhizin inhibits IL-8 production and NF-kB activity in lung epithelial cells, but not through glucocorticoid receptors, J. Pharmacol. Sci, 2008 , 106, 460-468.

18) I. Kuwahara, E.P. Lillehoj, W. Lu, I.S. Singh, Y. Isohama, T. Miyata, and K.C. Kim, Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-κB activation via EGFR transactivation in a lung epithelial cell line, Am. J. Physiol. Lung. Cell. Mol. Physiol., 2006, 291, 407-416.

19) I. Kuwahara, E.P. Lillehoj, T. Koga, Y. Isohama, T. Miyata, and K.C. Kim, The Signaling Pathway Involved in Neutrophil Elastase- Stimulated MUC1 Transcription, Am. J. Physiol. Lung. Cell. Mol. Physiol., 2005, 289, 355-362.

20) T. Koga, I. Kuwahara, E.P. Lillehoj, W. Lu, T. Miyata, Y. Isohama  and K.C. Kim, TNF-a induces MUC1 gene transcription in lung epithelial cells: its signaling pathway and biological implication, Am. J. Resp. Cell. Mol. Biol., 2007, 37, 691-698.


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