Fig. 4 ICAT-strategy

(a) Structure of ICAT-reagent, and strategy for quantifying differential protein expression.
　Two proteomes representing two different cell states have been treated with isotopically light and heavy ICAT-reagents, respectively. ICAT-reagent are introduced into cystein-contained peptide fragment. These cystein-peptide can be isolated by avidine-column.

(b) Example of solid phase ICAT-reagent