臓器置換を目指すオルガノイド研究の新展開

[参考文献]

1） K. Si-Tayeb, F. P. Lemaigre and S. A. Duncan, “Organogenesis and Development of the Liver.” Dev. Cell, 2010, 18, 175-189.

2） A. M. Zorn, Liver development, 2008

3） K. Matsumoto, H. Yoshitomi, J. Rossant and K. S. Zaret, “Liver organogenesis promoted by endothelial cells prior to vascular function.” Science, 2001, 294, 559-556.

4） T. Takebe, K. Sekine, M. Enomura, H. Koike, M. Kimura, T. Ogaeri, et al. “Vascularized and functional human liver from an iPSC-derived organ bud transplant.” Nature, 2013, 499（7459）, 481-484.

5） T. Takebe, M. Enomura, E. Yoshizawa, M. Kimura, H. Koike, Y. Ueno, et al. “Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation.” Cell Stem. Cell, 2015. 16, 556-565.

6） J. G. Camp, et al., “Multilineage communication regulates human liver bud development from pluripotency.” Nature, 2017, 546（7659）, 533-538.

7） T. Takebe, B. Zhang and M. Radisic. “Synergistic Engineering： Organoids Meet Organs-on-a-Chip.” Cell Stem. Cell, 2017, 21（3）, 297-300.

8） H. Iwashita, et al., “Secreted Cerberus1 as a marker for quantification of definitive endoderm differentiation of the pluripotent stem cells”, PloS ONE., 2013, 8（5）, e64291.